Trifluoroacetic acid → (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano(3,4-f)indolizine-3,6,10(4H)-trione

HRID 1267596ノート

反応式

HRID 1267596 の反応式
FC(F)(F)C(O)=O.[CH2:8]([C@:10]1([OH:29])[C:22]2[CH:21]=[C:20]3[N:16]([CH2:17][CH2:18][C:19]43OCC[O:23]4)[C:15](=[O:27])[C:14]=2[CH2:13][O:12][C:11]1=[O:28])[CH3:9]>C(OCC)(=O)C>[CH2:8]([C@:10]1([OH:29])[C:22]2[CH:21]=[C:20]3[N:16]([CH2:17][CH2:18][C:19]3=[O:23])[C:15](=[O:27])[C:14]=2[CH2:13][O:12][C:11]1=[O:28])[CH3:9]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 10902872(4'S)-4'-Ethyl-7',8'-dihydro-4'-hydroxyspiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione

生成物 1

HCID 10220900(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano(3,4-f)indolizine-3,6,10(4H)-trione収率 80%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To 90 ml of 90% trifluoroacetic acid, 3.5 g of (4S)-4-ethyl-6,6-(ethylenedioxy)-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,10(4H)-dione were added at room temperature over 5 minutes, followed by stirring at the same temperature for 30 minutes. After completion of the reaction, the solvent was removed under reduced pressure, followed by the thorough removal of the solvent by a vacuum pump. To the residue so obtained was added 20 ml of ethyl acetate. The crystals precipitated were collected by filtration, whereby 2.4 g of the title compound were obtained.

後処理

  1. customAfter completion of the reaction
  2. customthe solvent was removed under reduced pressure
  3. customfollowed by the thorough removal of the solvent by a vacuum pump
  4. customTo the residue so obtained
  5. customThe crystals precipitated
  6. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-57e589ffed4a4c76932f2ee53b9523db
出典データセット
uspto-grants-2003_04
特許番号
US06552197B2

反応ノート

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