反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH2:15][OH:16])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]>C(O)C.[Pd]>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([CH2:13][CH2:14][CH2:15][OH:16])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]参加物
4
実験手順
3-(3,4,5-Trimethoxyphenyl) -2-propen-1-ol (120 mg) was dissolved in ethanol, and to the solution 10% palladium on carbon (60 mg) was added, and the mixture was stirred at room temperature for 3 hours under a hydrogen atmosphere. The reaction mixture was filtered through celite, the filtrate was then concentrated under reduced pressure and extracted with chloroform. The resultant organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:methanol=14:1) to obtain the title compound.
後処理
- filtrationThe reaction mixture was filtered through celite
- concentrationthe filtrate was then concentrated under reduced pressure
- extractionextracted with chloroform
- washThe resultant organic layer was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
- customThe residue was purified by column chromatography on silica gel (chloroform:methanol=14:1)
出典と根拠
- ORDレコード
- ord-a780be377630457893f2f3726ff7fcfa
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06552188B2
関連ノート
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