Water → Heptane, 1,1,1,2,2-pentafluoro-7-iodo-
反応式
[I-:1].[Na+].CS(O[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])(=O)=O.O>CC(C)=O>[I:1][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15]参加物
5
実験手順
Sodium iodide (27.37 g, 182.58 mmol) was added to a solution of 1-methanesulfonyloxy-6,6,7,7,7-pentafluoroheptane (17.3 g, 60.86 mmol) in acetone (500 ml), followed by heating under reflux for 12 hours. Water was added to the reaction mixture, which was then extracted twice with ether. The combined organic layers were washed with 1% aqueous sodium thiosulfate and saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. The solvent was distilled off to give 1-iodo-6,6,7,7,7-pentafluoroheptane (16.5 g, Yield 86%).
後処理
- temperatureby heating
- temperatureunder reflux for 12 hours
- extractionwas then extracted twice with ether
- washThe combined organic layers were washed with 1% aqueous sodium thiosulfate and saturated aqueous sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off
出典と根拠
- ORDレコード
- ord-7bbe72cc1170415ab3449aaf4b88d62a
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06552068B1
反応ノート
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