5H-(1)Benzopyrano(4,3-c)pyridine, 1,2,3,4-tetrahydro-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy- → 5,5-Dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

HRID 126796

反応式

HRID 126796 の反応式
[CH3:1][C:2]1([CH3:26])[C:21]2[CH2:22][CH2:23][NH:24][CH2:25][C:20]=2[C:5]2[C:6]([OH:19])=[CH:7][C:8]([CH:10]([CH:12]([CH3:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:11])=[CH:9][C:4]=2[O:3]1>[Pd].C1(C)C(C)=CC=CC=1>[CH3:26][C:2]1([CH3:1])[C:21]2=[CH:22][CH:23]=[N:24][CH:25]=[C:20]2[C:5]2[C:6]([OH:19])=[CH:7][C:8]([CH:10]([CH:12]([CH3:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:11])=[CH:9][C:4]=2[O:3]1

参加物

4

反応物 1

HCID 2135435H-(1)Benzopyrano(4,3-c)pyridine, 1,2,3,4-tetrahydro-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-

生成物 1

HCID 197814025,5-Dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 7237O-Xylene溶媒

実験手順

A mixture of 4.20 g. of 5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine, 0.8 g. of 10% palladium on carbon and 80 ml. of xylene was stirred and refluxed for 25 hours. After cooling, the catalyst was removed by filtration. The filtrate was evaporated in vacuo and the product was recrystallized from autonitrile; m.p. 155°-157°.

後処理

  1. additionA mixture of 4.20 g
  2. temperaturerefluxed for 25 hours
  3. temperatureAfter cooling
  4. customthe catalyst was removed by filtration
  5. customThe filtrate was evaporated in vacuo
  6. customthe product was recrystallized from autonitrile

出典と根拠

ORDレコード
ord-62e66fd39837453fa9f80da2252cafb7
出典データセット
uspto-grants-1981_03
特許番号
US04254116

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