Acetic Anhydride → 10-Acetoxy-5,5-dimethyl-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

HRID 126797

反応式

HRID 126797 の反応式
[CH3:1][C:2]1([CH3:26])[C:21]2=[CH:22][CH:23]=[N:24][CH:25]=[C:20]2[C:5]2[C:6]([OH:19])=[CH:7][C:8]([CH:10]([CH:12]([CH3:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:11])=[CH:9][C:4]=2[O:3]1.[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[C:27]([O:19][C:6]1[C:5]2[C:20]3[C:21]([C:2]([CH3:1])([CH3:26])[O:3][C:4]=2[CH:9]=[C:8]([CH:10]([CH:12]([CH3:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:11])[CH:7]=1)=[CH:22][CH:23]=[N:24][CH:25]=3)(=[O:29])[CH3:28]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 197814025,5-Dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

生成物 1

HCID 2028784710-Acetoxy-5,5-dimethyl-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 3.53 g. (0.01 mole) of 5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine, 1.22 g. (0.012 mole) of acetic anhydride, and 5 ml. of pyridine was stirred at room temperature for 24 hours. The reaction mixture was evaporated in vacuo, and the residue was taken up in ether. The ether solution was washed with water, dried with anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on a Florosil® activated aluminum magnesium silicate 22 mm×30 inch column with chloroform to give the pure product.

後処理

  1. additionA mixture of 3.53 g
  2. customThe reaction mixture was evaporated in vacuo
  3. washThe ether solution was washed with water
  4. dry with materialdried with anhydrous sodium sulfate
  5. customevaporated in vacuo
  6. customThe residue was purified by chromatography on a Florosil® activated aluminum magnesium silicate 22 mm×30 inch column with chloroform
  7. customto give the pure product

出典と根拠

ORDレコード
ord-088bf249f04d472f82e640deba12184c
出典データセット
uspto-grants-1981_03
特許番号
US04254116

関連ノート

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