Nitric Acid → 2-Isopropyl-4-nitrophenol
反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].[N+:11]([O-])([OH:13])=[O:12].O>C(O)(=O)C>[CH:1]([C:4]1[CH:9]=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2]参加物
5
実験手順
To a solution of 2-isopropylphenol (4.1 ml) in acetic acid (30 ml) was added 69% nitric acid (4 ml) in an ice bath and the mixture was stirred at the same temperature for 30 minutes. After addition of iced water, the reaction mixture was extracted with t-butyl methyl ether. The extractant was washed with water and brine, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=4/1 as an eluant to give the desired compound (2.66 g, yield 49%) as a yellow solid.
後処理
- extractionthe reaction mixture was extracted with t-butyl methyl ether
- washThe extractant was washed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationthe filtrate concentrated in vacuo
- customThe residue was purified by chromatography on a silica gel column
出典と根拠
- ORDレコード
- ord-425b21d7ec7e4456bab2528b0a34dd38
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06555556B1
反応ノート
読み込み中…