Acetonitrile → 3-Carboxy-1-(3-trifluoromethylphenyl)-2-pyrrolidinone

反応式

[C:1]1([C:7]([OH:9])=O)([C:4]([OH:6])=[O:5])[CH2:3][CH2:2]1.[F:10][C:11]([F:20])([F:19])[C:12]1[CH:18]=[CH:17][C:15](N)=[CH:14][CH:13]=1.C(#[N:23])C>>[C:4]([CH:1]1[CH2:2][CH2:3][N:23]([C:14]2[CH:15]=[CH:17][CH:18]=[C:12]([C:11]([F:20])([F:19])[F:10])[CH:13]=2)[C:7]1=[O:9])([OH:6])=[O:5]

参加物

反応物 3

HCID 6342Acetonitrile

HCID 99644-(Trifluoromethyl)aniline

HCID 690171,1-Cyclopropanedicarboxylic acid

生成物 1

HCID 155160613-Carboxy-1-(3-trifluoromethylphenyl)-2-pyrrolidinone収率 38.8%

実験手順

10.0 g of 1,1-cyclopropanedicarboxylic acid and 12.4 g of 4-trifluoromethylaniline were added to 15 ml of acetonitrile, followed by refluxing for 7 hours with heating and stirring. The subsequent operation was conducted in the same manner as in Example 2 to obtain 7.1 g of an intended compound at a yield of 38.8%.