Hydrogen Bromide → 1-(3-bromopropyl)-5,6-dichloro-1,3-dihydro-2H-benzimidazol-2-one
反応式
[Cl:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]2[N:6]([CH2:10][CH2:11][CH2:12]O)[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[BrH:17]>O>[Br:17][CH2:12][CH2:11][CH2:10][N:6]1[C:5]2[CH:14]=[C:15]([Cl:16])[C:2]([Cl:1])=[CH:3][C:4]=2[NH:8][C:7]1=[O:9]参加物
4
実験手順
A mixture of 57.5 parts of 5,6-dichloro-1,3-dihydro-1-(3-hydroxypropyl)-2H-benzimidazol-2-one and 450 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 2.50 hours. The reaction mixture is cooled and water is added. The precipitated product is filtered off, stirred in 700 parts of water, filtered off again and dried in vacuo, yielding 59 parts (81%) of 1-(3-bromopropyl)-5,6-dichloro-1,3-dihydro-2H-benzimidazol-2-one; mp. 198.1° C.
後処理
- temperaturerefluxed for 2.50 hours
- temperatureThe reaction mixture is cooled
- filtrationThe precipitated product is filtered off
- stirringstirred in 700 parts of water
- filtrationfiltered off again
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-af68619533ab484c9d2788f36e347762
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04254127
反応ノート
読み込み中…