Acetic Anhydride → Ethyl 1-acetyl-4-piperidineacetate

HRID 126856

反応式

HRID 126856 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1>CC1C=CC=CC=1>[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 2760465Ethyl 2-(piperidin-4-yl)acetate

生成物 1

HCID 54363171Ethyl 1-acetyl-4-piperidineacetate収率 82%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 200 parts of acetic acid anhydride, 90 parts of ethyl 4-piperidineacetate and 225 parts of methylbenzene is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is diluted with water. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 92 parts (82%) of ethyl 1-acetyl-4-piperidineacetate as a residue.

後処理

  1. temperaturerefluxed for 3 hours
  2. customThe reaction mixture is evaporated
  3. additionthe residue is diluted with water
  4. extractionThe product is extracted with methylbenzene
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-3738f18a6d774f939670885c325dad30
出典データセット
uspto-grants-1981_03
特許番号
US04254127

関連ノート

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