2-Amino-4-methylpyridine → 2-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine

HRID 1268685

反応式

HRID 1268685 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1>C(O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 15332-Amino-4-methylpyridineHCID 74544-Bromophenacyl bromide

生成物 1

HCID 7176442-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine収率 56.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2,4′-dibromoacetophenone (22.4 g) and 2-amino-4-picoline (8.68 g) in ethanol (80 mL) was heated at reflux temperature for 3 hours. The reaction mixture was cooled to ambient temperature and the crystalline solid-isolated by filtration, washed with ethanol and dried in vacuo to give the title compound (13.1 g).

後処理

  1. temperaturewas heated
  2. temperatureat reflux temperature for 3 hours
  3. customthe crystalline solid-isolated by filtration
  4. washwashed with ethanol
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-0eb7891d007242a3b2069e7540f271dc
出典データセット
uspto-grants-2007_04
特許番号
US07199117B2

関連ノート

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