Cesium carbonate → 2-(4-Nitrophenyl)isothiazolidine 1,1-dioxide

HRID 1268818ノート

反応式

HRID 1268818 の反応式
C(=O)([O-])[O-].[Cs+].[Cs+].[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH2:20][CH2:21][CH2:22]Cl)(=[O:19])=[O:18])=[CH:12][CH:11]=1)([O-:9])=[O:8]>C(#N)C>[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:22][CH2:21][CH2:20][S:17]2(=[O:19])=[O:18])=[CH:12][CH:11]=1)([O-:9])=[O:8]

参加物

4

反応物 2

HCID 10796Cesium carbonateHCID 17988807N-(4-nitrophenyl)-3-chloropropane-1-sulfonamide

生成物 1

HCID 184468302-(4-Nitrophenyl)isothiazolidine 1,1-dioxide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
70 °C

実験手順

13.0 g (40.0 mmol) of caesium carbonate are added to a solution of 7.40 g (26.6 mmol) of N-(4-nitrophenyl)-3-chloropropane-1-sulfonamide in 150 ml of acetonitrile, and the mixture is stirred at 70° C. for 18 hours. The reaction mixture is subjected to conventional work-up, and the crude product is chromatographed on a silica-gel column using ethyl acetate/petroleum ether as eluent, giving 2-(4-nitrophenyl)isothiazolidine 1,1-dioxide as a yellowish solid; ESI 243.

後処理

  1. customthe crude product is chromatographed on a silica-gel column

出典と根拠

ORDレコード
ord-64fdfc45f6914ad981de0c7ea0a8efba
出典データセット
uspto-grants-2007_04
特許番号
US07199133B2

反応ノート

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