p-Toluenesulfonic acid → 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methoxymethylideneamino-4-trifluoromethylsulfinylpyrazole

HRID 1269377

反応式

HRID 1269377 の反応式
[CH3:1][O:2][CH:3](OC)OC.[CH:8]1[C:9]([C:30]([F:33])([F:32])[F:31])=[CH:10][C:11]([Cl:29])=[C:12]([N:15]2[N:19]=[C:18]([C:20]#[N:21])[C:17]([S+:22]([O-:27])[C:23]([F:26])([F:25])[F:24])=[C:16]2[NH2:28])[C:13]=1[Cl:14].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[C:20]([C:18]1[C:17]([S:22]([C:23]([F:24])([F:25])[F:26])=[O:27])=[C:16]([N:28]=[CH:3][O:2][CH3:1])[N:15]([C:12]2[C:13]([Cl:14])=[CH:8][C:9]([C:30]([F:31])([F:33])[F:32])=[CH:10][C:11]=2[Cl:29])[N:19]=1)#[N:21]

参加物

4

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 9005Trimethyl orthoformateHCID 178510672HCID 178510672、化合物2 回

生成物 1

HCID 727828043-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methoxymethylideneamino-4-trifluoromethylsulfinylpyrazole

実験手順

A substantial molar excess of trimethylorthoformat is reacted with fipronil (Compound IV) at reflux with 0.5 equivalents of paratoluensulfonic acid to provide 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methoxymethylideneamino-4-trifluoromethylsulfinylpyrazole (Compound III).

出典と根拠

ORDレコード
ord-73fbe05f322e4fe9a0a038e2fd9f4b19
出典データセット
uspto-grants-2007_04
特許番号
US07199246B2

関連ノート

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