Hydrochloric Acid → Ethyl 2-chloro-2-ethoxyacetate

HRID 126953

反応式

HRID 126953 の反応式
CO[CH2:3][CH2:4]OC.C(O)C.[ClH:10].[C:11]([O:15][CH2:16][CH3:17])(=[O:14])[CH:12]=[O:13]>O>[Cl:10][CH:12]([O:13][CH2:3][CH3:4])[C:11]([O:15][CH2:16][CH3:17])=[O:14]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 80711,2-DimethoxyethaneHCID 70211Ethyl oxoacetate

生成物 1

HCID 2724873Ethyl 2-chloro-2-ethoxyacetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a mixture of 10 ml. of 1,2-dimethoxyethane and 5.8 ml. of ethanol is passed 3.65 g. hydrogen chloride gas with cooling. Then 10.2 g of ethyl glyoxylate is added and after 24 hours at 25° C., 200 ml. of water and ice is added. The mixture is then extracted several times with ether and the extracts dried over anhydrous sodium sulfate. After evaporation of the extracts to an oil, the ethyl α-chloro-α-ethoxy-acetate so formed is added to a stirred mixture of 35.0 g. of sodium 4-(hexadecylamino)benzoate in 125 ml. of hexamethylphosphoramide. After 24 hours at 20° C., the product is obtained as white crystals by careful addition of water.

後処理

  1. additionInto a mixture of 10 ml
  2. extractionThe mixture is then extracted several times with ether
  3. dry with materialthe extracts dried over anhydrous sodium sulfate
  4. customAfter evaporation of the extracts to an oil

出典と根拠

ORDレコード
ord-366d262e502f480a8aabd130c51c6a61
出典データセット
uspto-grants-1981_03
特許番号
US04254138

関連ノート

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