Sulfuric Acid → HCID 86737540、化合物

HRID 126995ノート

反応式

HRID 126995 の反応式
[CH2:1]([O:8][C:9]([N:11]1[CH:15]([C:16]([OH:18])=[O:17])[CH2:14][C:13]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][C:25](=[CH2:27])[CH3:26].S(=O)(=O)(O)O>CCOCC>[CH2:1]([O:8][C:9]([N:11]1[CH:15]([C:16]([O:18][C:25]([CH3:27])([CH3:26])[CH3:24])=[O:17])[CH2:14][C:13]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 20288724(+/-)-4,5-Dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid

生成物 1

HCID 86737540HCID 86737540、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 6.6 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, 5 ml of isobutylene, 25 ml of ether and 0.25 ml of concentrated sulfuric acid is shaken in a pressure vessel for about 16 hours. The reaction vessel is vented (-10° C.) and the contents are washed with ice cold aqueous sodium hydroxide. The organic fraction is dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title compound.

後処理

  1. custom(-10° C.)
  2. washthe contents are washed with ice cold aqueous sodium hydroxide
  3. dry with materialThe organic fraction is dried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6b242c2ec9d541f9baf79fab80cb00b6
出典データセット
uspto-grants-1981_03
特許番号
US04254267

反応ノート

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