HCID 86737540、化合物 → (+/-)-4,5-Dihydro-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester

HRID 126996ノート

反応式

HRID 126996 の反応式
C(OC([N:11]1[CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][C:13]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[N:12]1)=O)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[S:24]1[CH:25]=[CH:26][CH:27]=[C:23]1[C:13]1[CH2:14][CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[NH:11][N:12]=1

参加物

5

反応物 2

HCID 86737540HCID 86737540、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 86737541(+/-)-4,5-Dihydro-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 5.0 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester in 75 ml of ethanol containing 0.5 g of 5% palladium on carbon is hydrogenated at atmospheric pressure until the uptake of hydrogen ceases. The catalyst is removed by filtration through Celite and the filtrate is concentrated in vacuo to yield the title compound.

後処理

  1. customThe catalyst is removed by filtration through Celite
  2. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-6f0aff55b685477b9f9edbd03f8521a5
出典データセット
uspto-grants-1981_03
特許番号
US04254267

反応ノート

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