Hydrogen Bromide → 4-(2-Oxo-1-cyclopentylidenemethyl)phenylacetic acid
反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][C:3]1=[CH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1.Br>O1CCOCC1>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][C:3]1=[CH:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:12][CH:13]=1参加物
4
実験手順
A mixture of 0.4 g of ethyl 4-(2-oxo-1-cyclopentylidenemethyl)phenylacetate in 100 ml of a 10% aqueous solution of hydrobromic acid and 10 ml of dioxane was heated under reflux for 1 hour. After cooling, the reaction mixture was extracted with ether, an ether layer was washed with water and dried. The ether was distilled off and the residual oily substance was distilled under reduced pressure to give 0.1 g of an oily substance having a boiling point of 205°-210° C./0.25 mmHg.
後処理
- temperaturewas heated
- temperatureunder reflux for 1 hour
- temperatureAfter cooling
- extractionthe reaction mixture was extracted with ether
- washan ether layer was washed with water
- customdried
- distillationThe ether was distilled off
- distillationthe residual oily substance was distilled under reduced pressure
- customto give 0.1 g of an oily substance
出典と根拠
- ORDレコード
- ord-f473556008f04e2dbf8d458f532c78a2
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04254274
反応ノート
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