HCID 18449243、化合物 → HCID 18449207、化合物
反応式
O[CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[C:8]([NH:17][CH:18]([CH3:20])[CH3:19])[C:9]3[N:10]2[C:13](=[O:16])[NH:14][N:15]=3)=[CH:5][CH:4]=1.[H][H]>CCO.[Pd]>[CH:18]([NH:17][C:8]1[C:9]2[N:10]([C:13](=[O:16])[NH:14][N:15]=2)[C:11]2[C:6]([N:7]=1)=[CH:5][CH:4]=[C:3]([CH3:2])[CH:12]=2)([CH3:20])[CH3:19]参加物
5
実験手順
A solution of 8-hydroxymethyl-4-isopropylamino-2H-[1,2,4]triazolo[4,3-a]quinoxalin-1-one (20 mg) in EtOH (15 mL) was treated 10% Pd/C (10 mg), and the mixture was agitated under 45 psi hydrogen atmosphere for 68 hrs. The reaction mixture was filtered through diatomaceous earth, the filtrate concentrated, and the residue purified by silica gel chromatography to provide the title compound as a solid. MS (M+H)+=258.0.
後処理
- filtrationThe reaction mixture was filtered through diatomaceous earth
- concentrationthe filtrate concentrated
- customthe residue purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-6eeba0f51812498f9e3e908452c97232
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07202245B2
反応ノート
読み込み中…