Morpholine → 4-(2,6-Difluoro-4-nitrophenyl)morpholine

HRID 1270334ノート

反応式

HRID 1270334 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1F>C(#N)C>[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 27827931,2,3-Trifluoro-5-nitrobenzene

生成物 1

HCID 223856304-(2,6-Difluoro-4-nitrophenyl)morpholine収率 88%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Morpholine (1.2 g, 14.12 mmol) was added to a stirring solution of 3,4,5-trifluoronitro benzene (1 g, 5.65 mmol) in acetonitrile (15 mL) and the reaction mixture was refluxed for 5 h. A viscous liquid was obtained upon concentration, which was then poured into crushed ice. The solid thus obtained was filtered off and dried under reduced pressure to obtain the title compound (1.2 g, 88%).

後処理

  1. temperaturethe reaction mixture was refluxed for 5 h
  2. customA viscous liquid was obtained upon concentration, which
  3. additionwas then poured
  4. custominto crushed ice
  5. customThe solid thus obtained
  6. filtrationwas filtered off
  7. customdried under reduced pressure

出典と根拠

ORDレコード
ord-d95740646ca04af786232cafb0cbef43
出典データセット
uspto-grants-2007_04
特許番号
US07202254B2

反応ノート

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