Sodium Iodide → 1-Iodooct-1-en-3-one

HRID 127071

反応式

HRID 127071 の反応式
Cl[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[I-:11].[Na+]>CC(C)=O>[I:11][CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 545149151-Chloro-1-octen-3-one

生成物 1

HCID 534008741-Iodooct-1-en-3-one収率 64.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 25 g (0.16 moles) of 1-chloro-1-octen-3-one (Example 187) and 35 g (0.23 moles) of sodium iodide in 200 ml of reagent acetone is stirred at the reflux temperature for 18 hours. The cooled mixture is filtered and the mother liquor taken to dryness. The residual oil is dissolved in benzene and the solution is washed with 5% sodium thiosulfate solution, saturated sodium chloride solution, dried and taken to dryness. The residual oil is crystallized from hexane to give 26 g of a white solid, mp 35°-37° C.; λ max 1670, 950 cm-1.

後処理

  1. filtrationThe cooled mixture is filtered
  2. dissolutionThe residual oil is dissolved in benzene
  3. washthe solution is washed with 5% sodium thiosulfate solution, saturated sodium chloride solution
  4. customdried
  5. customThe residual oil is crystallized from hexane

出典と根拠

ORDレコード
ord-f254d4f644f0407889810353044be2d7
出典データセット
uspto-grants-1981_03
特許番号
US04254285

関連ノート

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