化工社化工社 化学情報印刷レポート · 研究参考用
N-bromobutanimide → 4-Bromo-3,5-difluoroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 3,5-Difluoroaniline | HCID 96595 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Bromo-3,5-difluoroaniline | HCID 2736260 | — |
反応手順
3,5-Difluoroaniline (10.0 g, 77.5 mmol) is dissolved in DMF (100 mL). NBS (13.9 g, 78.0 mmol) is added portionwise at room temperature. After stirring overnight at room temperature, the reaction mixture is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil which is purified by column chromatography (methylene chloride/hexanes) to give 4-bromo-3,5-difluoroaniline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07202364B2 |
| 出典データセット | uspto-grants-2007_04 |
| ORD ID | ord-e552a0d6f13146c99cc37f51be6c777b |
| 出典メモ | uspto-grants-2007_04 |