反应详情

3,5-Difluoroaniline (10.0 g, 77.5 mmol) is dissolved in DMF (100 mL). NBS (13.9 g, 78.0 mmol) is added portionwise at room temperature. After stirring overnight at room temperature, the reaction mixture is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil which is purified by column chromatography (methylene chloride/hexanes) to give 4-bromo-3,5-difluoroaniline.

1. washwashed with brine
2. dry with materialThe separated organic phase is dried (Na2SO4)
3. concentrationconcentrated
4. customto give an oil which
5. customis purified by column chromatography (methylene chloride/hexanes)