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Chlorosuccinimide → 4-Bromo-2-chloro-3,5-difluoroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | 4-Bromo-3,5-difluoroaniline | HCID 2736260 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Bromo-2-chloro-3,5-difluoroaniline | HCID 18451521 | — |
反応手順
4-Bromo-3,5-difluoroaniline (10.5 g, 50.5 mmol) is dissolved in DMF (100 mL). NCS (28.6 g, 50.5 mmol) is added portionwise at room temperature. After 48 hours, the reaction is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil. The residue is purified by column chromatography (EtOAc/hexanes) to give 4-bromo-2-chloro-3,5-difluoroaniline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07202364B2 |
| 出典データセット | uspto-grants-2007_04 |
| ORD ID | ord-412f43e343fe4ce2a34aeef9f39f29dd |
| 出典メモ | uspto-grants-2007_04 |