反应详情

4-Bromo-3,5-difluoroaniline (10.5 g, 50.5 mmol) is dissolved in DMF (100 mL). NCS (28.6 g, 50.5 mmol) is added portionwise at room temperature. After 48 hours, the reaction is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil. The residue is purified by column chromatography (EtOAc/hexanes) to give 4-bromo-2-chloro-3,5-difluoroaniline.

1. washwashed with brine
2. dry with materialThe separated organic phase is dried (Na2SO4)
3. concentrationconcentrated
4. customto give an oil
5. customThe residue is purified by column chromatography (EtOAc/hexanes)