m-Chloroperbenzoic acid → N-(4-methoxyphenyl)-2-oxiran-2-ylacetamide
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:14])[CH2:11][CH:12]=[CH2:13])=[CH:5][CH:4]=1.ClC1C=CC=C(C(OO)=[O:23])C=1>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:14])[CH2:11][CH:12]2[CH2:13][O:23]2)=[CH:5][CH:4]=1参加物
4
実験手順
The solution of N-(4-methoxyphenyl)but-3-enamide (9) from the previous reaction was treated with m-chloroperbenzoic acid (2 eq.) and stirred at room temperature for 18 hours. The reaction mixture was diluted with dichloromethane, and washed with 1N sodium hydroxide. The organic phase was separated, dried over magnesium sulfate, filtered, and the filtrate evaporated under reduced pressure to give crude N-(4-methoxyphenyl)-2-oxiran-2-ylacetamide, a compound of formula (10).
後処理
- washwashed with 1N sodium hydroxide
- customThe organic phase was separated
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customthe filtrate evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-d46fb5af2e40471295de51925e8c9db5
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07205303B2
反応ノート
読み込み中…