Hydrochloric Acid → HCID 18451718、化合物
反応式
[CH3:1][C:2]1([C:7]2[S:11][C:10]([CH2:12][OH:13])=[CH:9][CH:8]=2)OCC[O:3]1.Cl.C(=O)([O-])O.[Na+]>C1COCC1>[OH:13][CH2:12][C:10]1[S:11][C:7]([C:2](=[O:3])[CH3:1])=[CH:8][CH:9]=1参加物
5
実験手順
To a solution of [5-(2-methyl-1,3-dioxolan-2-yl)thien-2-yl]methanol prepared in the above step in THF (240 ml) was added 1N hydrochloric acid (48 ml) and the mixture was stirred for 2 hours at room temperature. Thereto was added sodium hydrogencarbonate (4.04 g) and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 1-[5-(hydroxymethyl)thien-2-yl]ethanone. This product was used in the next step without purification.
後処理
- extractionthe mixture was extracted with ethyl acetate
- washThe organic layer was washed with a saturated aqueous sodium chloride solution
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-91b220445be84d42970bdaa003cf89da
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07205291B2
反応ノート
読み込み中…