Acetaldehyde → HCID 18452869、化合物

HRID 1271220ノート

反応式

HRID 1271220 の反応式
N[C:2]1C=NC=N[CH:7]=1.C(=O)C.[H][H].[CH2:13]([NH:15][C:16]1[CH:17]=[N:18][CH:19]=[N:20][CH:21]=1)[CH3:14]>C(O)C.O=[Pt]=O>[CH2:13]([N:15]([C:16]1[CH:17]=[N:18][CH:19]=[N:20][CH:21]=1)[CH2:2][CH3:7])[CH3:14]

参加物

7

反応物 4

HCID 177AcetaldehydeHCID 344373Pyrimidin-5-amineHCID 694722071368022-07-4HCID 178418361HCID 178418361、化合物

生成物 1

HCID 18452869HCID 18452869、化合物

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A suspension of the 5-aminopyrimidine, and one twenty-fifth an equal mass of PtO2, and 5 equivalents equivalents of aqueous acetaldehyde, in ethanol solvent, was shaken under 60 psi hydrogen gas for 24 h. At this time, TLC of an evaporated aliquot of the reaction mixture indicated complete conversion of the 5-(N-ethyl)aminopyrimidine. The Pt catalyst was removed by filtering the reaction mixture through Celite, and the 5-(N,N-diethyl)aminopyrimidine was isolated by evaporation of the ethanol solvent. The crude product was purified by flash chromatography on silica using EtOAc/hexanes.

後処理

  1. customThe Pt catalyst was removed
  2. filtrationby filtering the reaction mixture through Celite

出典と根拠

ORDレコード
ord-d24865bc7b22419b8a1bf849372426e2
出典データセット
uspto-grants-2007_04
特許番号
US07205310B2

反応ノート

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