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HRID 1271301作成日：2026年10月27日
2-(4-Pentynyloxy)tetrahydro-2H-pyran → 5,6-Diphenyl-2-[5-(2-tetrahydropyranyloxy)-1-pentyn-1-yl]pyrazine
https://huagongshe.com/reaction/1271301
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(4-Pentynyloxy)tetrahydro-2H-pyran | HCID 357816 | — |
| 反応物 | 5-Chloro-2,3-Diphenylpyrazine | HCID 3654493 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 5,6-Diphenyl-2-[5-(2-tetrahydropyranyloxy)-1-pentyn-1-yl]pyrazine | HCID 22931955 | 75.8% |
反応手順
To a solution of 1.58 g of 2-chloro-5,6-diphenylpyrazine in 10 ml of triethylamine, 1.20 g of 5-(2-tetrahydropyranyloxy)-1-pentyne, 208 mg of dichlorobis(triphenylphosphine)palladium (II) and 56 mg of copper (I) iodide were added, followed by stirring under an argon atmosphere at 80° C. for 8 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in diethyl ether, and then the insoluble matter was removed by filtration through celite. After the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography to obtain 1.79 g of the desired compound as a brown oily substance.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07205302B2 |
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| 出典データセット | uspto-grants-2007_04 |
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| ORD ID | ord-30c9cb5a484e4641a505c92c2d64f0e7 |
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| 出典メモ | uspto-grants-2007_04 |
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