反应详情

温度

80 °C

To a solution of 1.58 g of 2-chloro-5,6-diphenylpyrazine in 10 ml of triethylamine, 1.20 g of 5-(2-tetrahydropyranyloxy)-1-pentyne, 208 mg of dichlorobis(triphenylphosphine)palladium (II) and 56 mg of copper (I) iodide were added, followed by stirring under an argon atmosphere at 80° C. for 8 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in diethyl ether, and then the insoluble matter was removed by filtration through celite. After the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography to obtain 1.79 g of the desired compound as a brown oily substance.

1. customThe solvent was evaporated under reduced pressure
2. dissolutionthe residue was dissolved in diethyl ether
3. customthe insoluble matter was removed by filtration through celite
4. customAfter the solvent was evaporated under reduced pressure
5. customthe residue was purified by silica gel column chromatography