Methylamine → N-(4-methyl-1,3-dioxan-2-ylmethyl)methylamine
反応式
Br[CH2:2][CH:3]1[O:8][CH:7]([CH3:9])[CH2:6][CH2:5][O:4]1.[OH-].[Na+].[CH3:12][NH2:13]>>[CH3:9][CH:7]1[CH2:6][CH2:5][O:4][CH:3]([CH2:2][NH:13][CH3:12])[O:8]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
2-bromomethyl-4-methyl-1,3-dioxane (160 grams) and 40% aqueous methylamine (150 ml) were charged into a pressure vessel and agitated for a period of about 6 hours at a temperature of about 50° C. under autogeneous pressure. The reaction mixture was cooled to room temperature and sodium hydroxide (40 grams) was added. The reaction mixture was then extracted with methylene chloride. The extract was dried and the methylene chloride stripped off using a rotary evaporator to yield the desired product N-(4-methyl-1,3-dioxan-2-ylmethyl)methylamine.
後処理
- temperatureThe reaction mixture was cooled to room temperature
- extractionThe reaction mixture was then extracted with methylene chloride
- customThe extract was dried
- customa rotary evaporator
出典と根拠
- ORDレコード
- ord-fe87e18df2f843abb07459b083fed972
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04255182
反応ノート
読み込み中…