HCID 11287642、化合物 → 3-(Carboxymethoxy)isoxazole-5-carboxylic acid

HRID 1271603ノート

反応式

HRID 1271603 の反応式
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:6]=1)=[O:4]>CO.[OH-].[Na+]>[C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([OH:14])=[O:13])[CH:6]=1)([OH:4])=[O:2]

参加物

4

反応物 1

HCID 11287642HCID 11287642、化合物

生成物 1

HCID 111481453-(Carboxymethoxy)isoxazole-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of ethyl (5-(methoxycarbonyl)isoxazol-3-yl)oxyacetate (4 mmol, Example 73) in methanol (60 mL) and 5% aqueous NaOH is heated at reflux for 1 hour. At the end of this time, the methanol is removed, the residue diluted with additional water, and acidified to pH=4 with hydrochloric acid. The resulting precipitate is collected by filtration, washed with cold water, and dried.

後処理

  1. temperatureat reflux for 1 hour
  2. customAt the end of this time, the methanol is removed
  3. additionthe residue diluted with additional water
  4. filtrationThe resulting precipitate is collected by filtration
  5. washwashed with cold water
  6. customdried

出典と根拠

ORDレコード
ord-da2bc9314ef045648f0c48a5a66a5cf0
出典データセット
uspto-grants-2007_04
特許番号
US07205403B2

反応ノート

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