HCID 9888784、化合物 → (R)-(-)-1-(3,4-di(t-butyldimethylsiloxy)phenyl)-2-aminoethanol

HRID 1271622ノート

反応式

HRID 1271622 の反応式
[O:1]([C:9]1[CH:10]=[C:11]([C@@H:23]([OH:28])[CH2:24][N+:25]([O-])=O)[CH:12]=[CH:13][C:14]=1[O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].[H][H]>CO.[Pd]>[O:1]([C:9]1[CH:10]=[C:11]([C@@H:23]([OH:28])[CH2:24][NH2:25])[CH:12]=[CH:13][C:14]=1[O:15][Si:16]([C:19]([CH3:21])([CH3:20])[CH3:22])([CH3:18])[CH3:17])[Si:2]([C:5]([CH3:8])([CH3:6])[CH3:7])([CH3:4])[CH3:3]

参加物

5

反応物 2

HCID 9888784HCID 9888784、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 15313692(R)-(-)-1-(3,4-di(t-butyldimethylsiloxy)phenyl)-2-aminoethanol収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

100 mg of optically active 1-(3,4-di(t-butyldimethylsiloxy)phenyl)-2-nitroethanol obtained in example 1 was dissolved in 10 ml of methanol, and 10 mg of 10% Pd/C was added to the solution, after which the mixture was reacted at 20° C. under the hydrogen pressure of 0.1 MPa for 20 hours, so as to obtain 89.3 mg of the intended compound (in a yield of 96%, with an optical purity of 94% e.e.).

出典と根拠

ORDレコード
ord-e16873283ad2432a87ace7d79e231644
出典データセット
uspto-grants-2007_04
特許番号
US07205425B2

反応ノート

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