2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone

HRID 1271682

反応式

HRID 1271682 の反応式
[C:1](C1NC=CN=1)(C1NC=CN=1)=[O:2].[NH2:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[OH:21]>ClCCl>[F:20][C:18]1[CH:17]=[CH:16][C:15]2[O:21][C:1](=[O:2])[NH:13][C:14]=2[CH:19]=1

参加物

4

反応物 2

HCID 27359172-Amino-4-fluorophenolHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

生成物 1

HCID 2872085-Fluoro-2(3H)-benzoxazolone収率 67%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).

後処理

  1. washAfter 14 hours the solution was washed with 5M aqueous HCl, water
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe solution was filtered through a plug of silica
  4. customevaporated

出典と根拠

ORDレコード
ord-4546198c3ac949d9ac091528485bf21a
出典データセット
uspto-grants-2007_04
特許番号
US07205408B2

関連ノート

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