化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-4-fluorophenol | HCID 2735917 | — |
| 反応物 | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-Fluoro-2(3H)-benzoxazolone | HCID 287208 | 67% |
反応手順
Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07205408B2 |
| 出典データセット | uspto-grants-2007_04 |
| ORD ID | ord-4546198c3ac949d9ac091528485bf21a |
| 出典メモ | uspto-grants-2007_04 |