2-Bromoethanol → 2-(2-Iodo-6-methylpyridin-3-yloxy)ethanol

HRID 1271687ノート

反応式

HRID 1271687 の反応式
[I:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.Br[CH2:11][CH2:12][OH:13]>[OH-].[Na+]>[I:1][C:2]1[C:7]([O:8][CH2:11][CH2:12][OH:13])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1

参加物

4

反応物 2

HCID 108982-BromoethanolHCID 899572-Iodo-6-methylpyridin-3-ol

生成物 1

HCID 218737982-(2-Iodo-6-methylpyridin-3-yloxy)ethanol

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
100 °C

実験手順

2-Iodo-6-methyl-pyridin-3-ol (6.49 g, 27.6 mmol) was stirred in a 1M solution of sodium hydroxide (30 ml). To this was added 1-bromoethan-2-ol (3.91 ml, 55.20 mmol) dropwise at room temperature. The resulting solution was then heated to 100° C. and stirred for 2 hours. The reaction mixture was cooled and then extracted into chloroform (2×100 ml). The organic phases were combined and extracted with a solution of 1M sodium hydroxide (25 ml). The organic phase was then dried over magnesium sulfate and concentrated in vacuo. This provided the desired product which was used without further purification (5.26 g).

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted into chloroform (2×100 ml)
  3. extractionextracted with a solution of 1M sodium hydroxide (25 ml)
  4. dry with materialThe organic phase was then dried over magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-55d71aeb95da414f97dd5dd9a07b5e13
出典データセット
uspto-grants-2007_04
特許番号
US07205408B2

反応ノート

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