5-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione → 3-[5-(6-Chloro-pyridin-3-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde

HRID 12717ノート

反応式

HRID 12717 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16](OC)[O:17]C)[CH:13]=2)=[CH:4][CH:3]=1>C1COCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16]=[O:17])[CH:13]=2)=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 589941995-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione

生成物 1

HCID 589942093-[5-(6-Chloro-pyridin-3-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
40 °C

実験手順

5-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep92, 267 mg, 0.82 mmol) was dissolved in THF (10 ml) and then 1N HClaq (0.82 ml) was added. The solution was stirred at 40° C. for 1.5 hours. TEA (116 μl, 0.83 mmol) was added and the solvent was removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).

後処理

  1. addition1N HClaq (0.82 ml) was added
  2. customthe solvent was removed in vacuum at room temperature
  3. customdried
  4. customto give a white powder that
  5. customwas used in the next step without further purification (quantitative yield)

出典と根拠

ORDレコード
ord-06092e2182fb448f8c85e017bcd16aec
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

反応ノート

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