Thionyl Chloride → 4-(2-oxopyridin-1(2H)-yl)benzoyl chloride
反応式
[O:1]=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1.O=S(Cl)[Cl:19]>ClCCCl>[O:1]=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:19])=[O:13])=[CH:10][CH:9]=1参加物
4
実験手順
4-(2-oxopyridin-1(2H)-yl)benzoic acid (1 g, 4.6 mmol) was ]mixed with 10 mL of 1,2-dichloroethane. To this suspension was added SOCl2 (6 mL), and the mixture was refluxed for 1.5 h. The mixture was reduced in vacuo. The remaining traces of SOCl2 were removed by adding 1,2-dichloroethane (2×5 mL) and evaporating to dryness to yield 4-(2-oxopyridin-1(2H)-yl)benzoyl chloride as a white solid.
後処理
- temperaturethe mixture was refluxed for 1.5 h
- customThe remaining traces of SOCl2 were removed
- additionby adding 1,2-dichloroethane (2×5 mL)
- customevaporating to dryness
出典と根拠
- ORDレコード
- ord-9a3b8b62b1204cdc908ca53f8022c1a0
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07205318B2
反応ノート
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