Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride

HRID 127179

反応式

HRID 127179 の反応式
[ClH:1].O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>C(O)(=O)C>[ClH:1].[ClH:1].[CH3:9][C:8]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:3][S:14][CH2:13][CH2:12][NH2:11]

参加物

4

反応物 2

HCID 9082Cysteamine HydrochlorideHCID 30847074-Methylimidazol-5-ylmethanolhydrochloride

生成物 1

HCID 30159992-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride収率 184.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30 g) and cysteamine hydrochloride (23 g) in acetic acid (200 ml) was heated under reflux for 10 hours. Following cooling to 15°-20° C., the solid which crystallised was collected and washed with isopropyl alcohol to give 2[(5-methylimidazol-4-yl)methyl]thioethylamine dihydrochloride (45.5 g), m.p. 189°-192° C.

後処理

  1. temperatureunder reflux for 10 hours
  2. temperatureFollowing cooling to 15°-20° C.
  3. customthe solid which crystallised
  4. customwas collected
  5. washwashed with isopropyl alcohol

出典と根拠

ORDレコード
ord-3182308200444c808de3514923d8ef8d
出典データセット
uspto-grants-1981_03
特許番号
US04255425

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