6-Methoxypyridine-3-carbaldehyde → Ethyl 3-(6-methoxy-3-pyridyl)acrylate
反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=O)=[CH:5][CH:4]=1.[C:11]([O:17][CH2:18][CH3:19])(=[O:16])[CH2:12]C([O-])=O>N1CCCCC1.N1C=CC=CC=1>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[CH:12][C:11]([O:17][CH2:18][CH3:19])=[O:16])=[CH:5][CH:4]=1参加物
5
実験手順
A mixture of 6-methoxypyridine-3-carboxaldehyde (2.34 g), monoethyl malonate (4.51 g), pyridine (12 ml) and piperidine (6 drops) was heated under reflux for 5 hours and was evaporated to an oil. This oil was partitioned between ether and dilute aqueous ammonia. The ether layer was washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methoxy-3-pyridyl)acrylate (2.8 g, 79%), m.p. 49-52°.
後処理
- temperaturewas heated
- temperatureunder reflux for 5 hours
- customwas evaporated to an oil
- customThis oil was partitioned between ether and dilute aqueous ammonia
- washThe ether layer was washed with water
- customevaporated to an oil which
- customcrystallised
出典と根拠
- ORDレコード
- ord-0e168bd7f1a34e58b18e711c954c5def
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04255428
反応ノート
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