Methanol → 2-Methoxyisonicotinonitrile

HRID 127201

反応式

HRID 127201 の反応式
[Na].Cl[C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1.[CH3:11][OH:12]>>[CH3:11][O:12][C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1

参加物

4

反応物 3

HCID 887MethanolHCID 5686382-Chloro-4-cyanopyridineHCID 5360545Sodium

生成物 1

HCID 72048872-Methoxyisonicotinonitrile収率 51%

実験手順

Sodium (20.8 g) was dissolved in methanol (285 ml), a solution of 2-chloro-4-cyanopyridine (115.53 g) in methanoldioxan (1:1, 850 ml) was added and the mixture was boiled under reflux for 21/2 hours and was allowed to cool. The mixture was filtered and the volume of the filtrate was reduced by evaporation in 200 ml and water (400 ml) was added. The solid which precipitated out was filtered off to give 2-methoxy-4-cyanopyridine (57.2 g, 51%), m.p. 93-95.5°.

後処理

  1. temperatureunder reflux for 21/2 hours
  2. temperatureto cool
  3. filtrationThe mixture was filtered
  4. customthe volume of the filtrate was reduced by evaporation in 200 ml and water (400 ml)
  5. additionwas added
  6. customThe solid which precipitated out
  7. filtrationwas filtered off

出典と根拠

ORDレコード
ord-c53e5f015c9a439dbf227b810b1f574a
出典データセット
uspto-grants-1981_03
特許番号
US04255428

関連ノート

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