戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 127206作成日：2026年10月26日

Ethanol → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone

https://huagongshe.com/reaction/127206

反応式

関与物質

役割名称HCID仕込み量
反応物EthanolHCID 702—
反応物4-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 665568—
反応物2-Nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidoneHCID 12783834—
溶媒IsopropanolHCID 3776—
生成物2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidoneHCID 12788678—

反応手順

Reaction of 2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone with 1.06 molar equivalents of 2-(5-methyl-4-imidazolylmethylthio)ethylamine in refluxing ethanol for 24 hours gave 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone, m.p. 128-130° (from 2-propanol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US04255428
出典データセットuspto-grants-1981_03
ORD IDord-06d75e9eee97420e980a2f62bef5b330
出典メモuspto-grants-1981_03