Trifluoroacetic acid → 2-(Thiophen-2-yl)ethene-1-sulfonamide

HRID 1272073ノート

反応式

HRID 1272073 の反応式
CC([NH:9][S:10](/[CH:13]=[CH:14]/[C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)(=[O:12])=[O:11])(C)CC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[S:16]1[CH:17]=[CH:18][CH:19]=[C:15]1/[CH:14]=[CH:13]/[S:10]([NH2:9])(=[O:11])=[O:12]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86609959(E)-2-thiophen-2-yl-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide

生成物 1

HCID 149124362-(Thiophen-2-yl)ethene-1-sulfonamide収率 89%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(E)-2-Thiophen-2-yl-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (5.17 g, 17.2 mmol) was stirred for 15 minutes in a 1:1 mixture of trifluoroacetic acid and dichloromethane (40 mL). The mixture was concentrated in vacuo to afford a solid that was washed with dichloromethane (10 mL) in heptane (100 mL). The resultant solid was collected by suction filtration and dried under vacuum at ambient temperature to afford (E)-2-thiophen-2-yl-ethenesulfonic acid amide (2.89 g, 89%).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford a solid
  3. washthat was washed with dichloromethane (10 mL) in heptane (100 mL)
  4. filtrationThe resultant solid was collected by suction filtration
  5. customdried under vacuum at ambient temperature

出典と根拠

ORDレコード
ord-88b24be435f94396b95691f0d47bafb1
出典データセット
uspto-grants-2007_04
特許番号
US07208506B2

反応ノート

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