Trifluoroacetic acid → 2-(Thiophen-2-yl)ethene-1-sulfonamide

HRID 1272080ノート

反応式

HRID 1272080 の反応式
CC([NH:9][S:10](/[CH:13]=[CH:14]/[C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)(=[O:12])=[O:11])(C)CC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[S:16]1[CH:17]=[CH:18][CH:19]=[C:15]1/[CH:14]=[CH:13]/[S:10]([NH2:9])(=[O:11])=[O:12]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86609959(E)-2-thiophen-2-yl-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide

生成物 1

HCID 149124362-(Thiophen-2-yl)ethene-1-sulfonamide収率 89%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(E)-2-Thiophen-2-yl-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (5.17 g, 17.2 mmol) was stirred for 15 minutes in a 1:1 mixture of trifluoroacetic acid and dichloromethane (40 mL). The mixture was concentrated in vacuo to afford a solid that was washed with dichloromethane (10 mL) in heptane (100 mL). The resultant solid was collected by suction filtration and dried under vacuum at ambient temperature to afford (E)-2-thiophen-2-yl-ethenesulfonic acid amide (2.89 g, 89%).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford a solid
  3. washthat was washed with dichloromethane (10 mL) in heptane (100 mL)
  4. filtrationThe resultant solid was collected by suction filtration
  5. customdried under vacuum at ambient temperature

出典と根拠

ORDレコード
ord-9bd2d0fefc85440e8a56200460a461ff
出典データセット
uspto-grants-2007_04
特許番号
US07208506B2

反応ノート

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