Hydroxyamine hydrochloride → 4-Fluoro-2-(5-isoxazolyl)phenol
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]=[CH:6][C:5]2=[O:12].Cl.[NH2:14]O>C(O)C>[F:1][C:2]1[CH:11]=[CH:10][C:9]([OH:8])=[C:4]([C:5]2[O:12][N:14]=[CH:7][CH:6]=2)[CH:3]=1参加物
4
実験手順
The product from above (6-fluorochromen-4-one (5.25 g, 32.0 mmol) and hydroxylamine hydrochloride (4.65 g, 67.2 mmol) are dissolved in ethanol (180 ml) and the resulting mixture is heated to reflux. The reaction is allowed to stir for 18 hours before cooling and concentrating. The residue is taken up in toluene and filtered to give 690 mg of 4-fluoro-2-isoxazol-5-yl-phenol and from the filtrate 594 mg of 4-fluoro-2-isoxazol-3-yl-phenol.
後処理
- temperaturethe resulting mixture is heated to reflux
- temperaturebefore cooling
- concentrationconcentrating
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-4ac770502896430e878b8a40f36d127a
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07208505B2
反応ノート
読み込み中…