Trifluoroacetic acid → (1E)-2-(4-Chlorophenyl)ethenesulfonamide

HRID 1272355ノート

反応式

HRID 1272355 の反応式
CC([NH:9][S:10](/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)(=[O:12])=[O:11])(C)CC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:21][C:18]1[CH:17]=[CH:16][C:15](/[CH:14]=[CH:13]/[S:10]([NH2:9])(=[O:11])=[O:12])=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 17748075(E)-2-(4-chloro-phenyl)-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide

生成物 1

HCID 6212331(1E)-2-(4-Chlorophenyl)ethenesulfonamide収率 89.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To (E)-2-(4-chloro-phenyl)-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (5.0 g, 15.2 mmol) in dichloromethane (10 ml) was added trifluoroacetic acid (10 ml) and the mixture was stirred for 15 min. The mixture was concentrated in vacuo to afford a solid. The solid was washed with dichloromethane (5 ml) and heptane (150 ml). The resultant solid was collected by suction filtration. The solid was dried under vacuum at room temperature to afford (E)-2-(4-chloro-phenyl)-ethenesulfonic acid amide (2.95 g, 89%).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford a solid
  3. washThe solid was washed with dichloromethane (5 ml) and heptane (150 ml)
  4. filtrationThe resultant solid was collected by suction filtration
  5. customThe solid was dried under vacuum at room temperature

出典と根拠

ORDレコード
ord-f0e02833935c49e3bb4fd045b332985c
出典データセット
uspto-grants-2007_04
特許番号
US07208526B2

反応ノート

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