Sodium Carbonate → HCID 23452138、化合物

HRID 127317ノート

反応式

HRID 127317 の反応式
Cl.Cl.[CH3:3][N:4]([CH2:6][C:7]1[O:11][C:10]([CH2:12][S:13][CH2:14][CH2:15][NH2:16])=[CH:9][CH:8]=1)[CH3:5].[O-:17][C:18]#[N:19].[K+].C(=O)([O-])[O-].[Na+].[Na+]>O>[CH3:5][N:4]([CH2:6][C:7]1[O:11][C:10]([CH2:12][S:13][CH2:14][CH2:15][NH:16][C:18]([NH2:19])=[O:17])=[CH:9][CH:8]=1)[CH3:3]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 11378442Potassium cyanateHCID 189238085-{[(2-Aminoethyl)-thio]-methyl}-N,N-dimethyl-2-furanmethanamine dihydrochl

生成物 1

HCID 23452138HCID 23452138、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine dihydrochloride (2.8 g) and potassium cyanate (3.75 g) in water (50 ml) was heated on a steam bath for 8 hr. Excess solid sodium carbonate was added and organic material continually extracted with diethyl ether. The extracts were evaporated and the residue after column chromatography yielded N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]urea as a waxy solid (1.28 g). Analysis Found: C, 48.22; H, 7.50; N, 15.61. C11H19N3O2S.H2O requires: C, 48.00; H, 7.63; N, 15.27%.

後処理

  1. extractionorganic material continually extracted with diethyl ether
  2. customThe extracts were evaporated

出典と根拠

ORDレコード
ord-0d3cd134293743ae8461c8af969972cc
出典データセット
uspto-grants-1981_03
特許番号
US04255440

反応ノート

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