HCID 58994249、化合物 → HCID 58994157、化合物

HRID 12735ノート

反応式

HRID 12735 の反応式
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[CH3:18])[C:9](=[O:19])[NH:8][C:7]1=[O:20]>C1COCC1>[CH3:18][C:17]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:10]1[C:9](=[O:19])[NH:8][C:7](=[O:20])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=1

参加物

3

反応物 1

HCID 58994249HCID 58994249、化合物

生成物 1

HCID 58994157HCID 58994157、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
40 °C

実験手順

1-(3,3-Dimethoxy-propyl)-5-(4-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione (Pre112, 100 mg, 0.32 mmol) was dissolved in THF (5 ml) and 1N HClaq (327 μl) was added. The solution was then stirred at 40° C. for 1.5 hours. TEA (45 μl) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give the title compound that was used in the next step without further purification (quantitative yield).

後処理

  1. addition1N HClaq (327 μl) was added
  2. customthe solvent was carefully removed in vacuum at room temperature
  3. customdried

出典と根拠

ORDレコード
ord-ec7bd10461df43f8b74b205be880fb9b
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

反応ノート

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