HCID 58994245、化合物 → 3-[5-(2-Fluoro-6-methyl-pyridin-3-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde
反応式
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[C:13]([F:19])=[N:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[C:9](=[O:20])[NH:8][C:7]1=[O:21]>C1COCC1>[F:19][C:13]1[C:12]([C:10]2[C:9](=[O:20])[NH:8][C:7](=[O:21])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=2)=[CH:17][CH:16]=[C:15]([CH3:18])[N:14]=1参加物
3
反応条件
- 温度
- 40 °C
実験手順
1-(3,3-Dimethoxy-propyl)-5-(2-fluoro-6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione (Prep16, 150 mg, 0.46 mmol) was dissolved in THF (4 ml) and then 1N HClaq (0.46 ml) was added. The solution was stirred at 40° C. for 1 hour. TEA (65 μl, 0.47 mmol) was added and the solvent was removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).