Methanol → 2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one

HRID 1274072

反応式

HRID 1274072 の反応式
[CH3:1][C:2]1[C:3]([N+:11]([O-])=O)=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[O:6].[CH3:14][OH:15]>[Pd]>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:3]=1[N:11]=[C:1]([C:2]1[CH:3]=[CH:4][C:14]([OH:15])=[CH:9][CH:10]=1)[NH:7][C:5]2=[O:6]

参加物

4

反応物 2

HCID 887MethanolHCID 32713713-Methyl-2-nitrobenzamide

生成物 1

HCID 1354713542-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

3-Methyl-2-nitrobenzamide (1.20 g, 6.7 mmol) was dissolved in methanol and 10% activated palladium on carbon catalyst (150 mg) was added. The reaction vessel was placed under an atmosphere of hydrogen, at ambient temperature and pressure, until no further hydrogen absorption was observed. The catalyst was removed by filtration of the reaction mixture through a pad of Celite™, which was pre-washed with methanol (150 ml). The solvent was removed under vacuum to give the required product in good yield. The product was used for subsequent reactions without further purification. Yield (0.97 g, 6.4 mmol, 97%), m.p. 145-147° C.

後処理

  1. additionwas added
  2. customwas placed under an atmosphere of hydrogen, at ambient temperature
  3. custompressure, until no further hydrogen absorption
  4. customThe catalyst was removed by filtration of the reaction mixture through a pad of Celite™, which
  5. washwas pre-washed with methanol (150 ml)
  6. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-f70cb71b2d6e4d27b26650ce00641735
出典データセット
uspto-grants-2000_12
特許番号
US06156739

関連ノート

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