Iodoethane → 1-Chloro-4-ethoxy-2-nitrobenzene

HRID 1274365ノート

反応式

HRID 1274365 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](I)[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH3:13]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 691274-Chloro-3-nitrophenol

生成物 1

HCID 2407341-Chloro-4-ethoxy-2-nitrobenzene収率 97.7%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 4-chloro-3-nitrophenol (5.00 g, 29 mmol) in acetone (50 ml) were added ethyl iodide (4.95 g, 32 mmol) and potassium carbonate (4.37 g, 32 mmol), followed by stirring at room temperature for 20 hours. After filtration of the insoluble matter, the filtrate was subjected to evaporation under reduced pressure to remove the solvent, and the residue was purified by silica gel column chromatography (eluent; chloroform) to give 4-ethoxy-1-chloro-2-nitrobenzene (5.71 g).

後処理

  1. filtrationAfter filtration of the insoluble matter
  2. customthe filtrate was subjected to evaporation under reduced pressure
  3. customto remove the solvent
  4. customthe residue was purified by silica gel column chromatography (eluent; chloroform)

出典と根拠

ORDレコード
ord-46792c3674284c289776725f648199e7
出典データセット
uspto-grants-2000_12
特許番号
US06156801

反応ノート

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