Tert-Butylamine → N-(tert-butyl)-3,5,6-trifluoropyridin-2-amine
反応式
F[C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[N:3]=1.[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>C(#N)C>[C:11]([NH:15][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[N:3]=1)([CH3:14])([CH3:13])[CH3:12]参加物
4
反応条件
- 温度
- 60 °C
実験手順
To 40 ml of acetonitrile were added 11.0 g of 2,3,5,6-tetrafluoropyridine and 18.5 g of t-butylamine, and the mixture was stirred at 60° C. for 3 days, and the solvent and the like were distilled off. To the residue was added 100 ml of chloroform, and the mixture was washed with 50 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 9.7 g of the title compound as a pale yellow oil.
後処理
- distillationthe solvent and the like were distilled off
- additionTo the residue was added 100 ml of chloroform
- washthe mixture was washed with 50 ml of distilled water
- dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-795d2d3a90b04db3b7920fb4248969ed
- 出典データセット
- uspto-grants-2000_12
- 特許番号
- US06156903
反応ノート
読み込み中…